Pharmacological Actions of Saikosaponins isolated from Bupleurum falcatum

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Abstract
The changes in rat hepatocytes that occur after a 4 days period of treatment with various kinds of saikosaponins were studied. The administration of saikosaponin a or d produced a marked decrease of microsomal enzyme activities, glucose-6-phosphatase and NADPH-cytochrome c reductase, and a significant increase of 5'-nucleotidase activity, whereas saikosaponin b1, b2 and c did not cause any change in enzyme activities. In the rats pretreated with saikosaponin, especially saikosaponin a or d, the remarkable inhibition of D-galactosamine induced hepatic injury was observed.