Granulocytic Ehrlichiosis in Mice Deficient in Phagocyte Oxidase or Inducible Nitric Oxide Synthase
Open Access
- 1 July 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (7) , 4361-4362
- https://doi.org/10.1128/iai.68.7.4361-4362.2000
Abstract
Mice deficient in phox (gp91phox−/−) or NOS2 (NOS2−/−) were infected with the agent of human granulocytic ehrlichiosis (HGE) to evaluate the importance of these pathways in the eradication of HGE bacteria. NOS2−/−mice had delayed clearance of the HGE agent in comparison to control or gp91phox−/−mice, suggesting that reactive nitrogen intermediates play a role in the early control of HGE.Keywords
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