Ethoxyresorufin O-deethylation by human liver microsomes.
Open Access
- 1 September 1986
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 22 (3) , 263-268
- https://doi.org/10.1111/j.1365-2125.1986.tb02885.x
Abstract
As a substrate for human liver microsomes, ethoxyresorufin appears to be metabolised by a group of cytochrome P450 isoenzymes which are inducible by cigarette smoking. Kinetic studies in microsomes from four human livers indicate that only one enzyme component is involved over the full substrate range. Ethoxyresorufin O-deethylation activity at both high and low substrate concentrations correlated with the high affinity component of ethoxycoumarin O-deethylation and of diphenyloxazole metabolism.This publication has 12 references indexed in Scilit:
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