Effect of Exogenous Progesterone on the Corpus Luteum of the Bred Ewe

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Abstract
Daily injections of 0.4 mg. progesterone per pound body weight were made into bred ewes for various periods of time. The ewes were slaughtered at 5, 13 and 25 days of gestation. The progesterone appeared to cause some suppression of normal corpus luteum growth, but there was no evidence of any regression from initial size during the period of progesterone injection. The greatest suppression of growth and of formation of functional cells occurred when injections were made during part or all of the first 13 days. However, there was no evidence of any lasting effect on the function of these corpora lutea as indicated by the continued maintenance of pregnancy after progesterone injections were terminated. Neither beneficial nor harmful effects on fertility percentage or embryological characteristics could be ascribed to the progesterone injections.

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