Familial Hypophosphatemia

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Abstract
THE occurrence of rachitic bone changes and hypophosphatemia responding only to large doses of vitamin D was described by Albright and his associates1 in 1937 as rickets resistant to vitamin D. Its familial occurrence, first reported by Christensen2 in 1941, led to the use of the term "familial hypophosphatemia." This designation now seems more appropriate in view of the fact that some of these patients may have hypophosphatemia without evidence of rachitic changes. In addition, the resistance to vitamin D is only relative since in all reported cases the patients have eventually responded to large doses of vitamin D. Winters . . .