DELAYED APPEARANCE OF INDUCED BACTERIAL MUTANTS

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Abstract
Experiments were designed to show the sequence of events in the development of streptomycin resistance in UV induced mutants. Following irradiation, both mutants and wild type cells undergo a physiological lag and are insensitive to killing by penicillin. Then both potential mutants and wild types divide and become sensitive to penicillin. The wild type continues to divide but the potential mutants cease division when segregation of the mutant nuclei has been accomplished. Thereafter, the mutants cease division and are insensitive to the penicillin until the mutant phenotype is expressed.