DEVELOPMENT IN VITRO OF CYTOTOXIC LYMPHOCYTES AGAINST MURINE CYTOMEGALOVIRUS
- 1 August 1979
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 57 (4) , 425-428
- https://doi.org/10.1038/icb.1979.42
Abstract
Lymphocytes cytotoxic for mouse embryo fibroblasts (MEF) infected with murine cytomegalovirus (MCMV) were produced by in vitro culture of "memory" spleen cells with UV-irradiated, MCMV-infected, MEF. Cytotoxic lymphocytes were developed from spleen cells of mice 10 to 240 days after infection with MCMV, The cytotoxic cells carried the theta and Ly 2 antigens, and were H-2 restricted in the recognition of infected target cells.Keywords
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