Oxygen Toxicity. Arterial and Internal Jugular Blood Gas Composition in Man During Inhalation of Air, 100% O2 and 2% CO2 in O2 at 3.5 Atmospheres Ambient Pressure

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Abstract
Addition of 2% CO2 to O2 inhaled at 3.5 atmospheres pressure in 4 subjects caused an average increase of internal jugular venous pO2 of nearly 1000 mm Hg above the level found during the breathing of O2 alone. Relationships of this finding to changes in brain pO2 and to O2 toxicity are discussed. It is proposed that an increased tension of inspired CO2 shortens the latent period of O2 toxicity, not by a direct action upon brain cells, but indirectly through a cerebral vasodilatation and the resulting rise in brain pO2.