Changes in Glycolysis of Rat Thymocytes after a Whole-body X-irradiation

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Abstract
The aerobic production of lactate by suspensions of thymocytes prepared from irradiated rats was considerably increased in the early phase after a whole-body x-irradiation with 400 R. Intracellular concentrations of intermediates and co-factors of glycolysis were measured at various times up to 6 hours after the irradiation. Fructose-1,6-diphosphate showed a remarkable increase in the cells of rats killed immediately after the exposure. The changes in the levels of intermediates suggest the enhanced activity of phosphofructokinase in thymocytes after whole-body irradiation, as previously observed following in vitro irradiation.