Antitumor activity of 13-methyl-berberrubine derivatives.

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Abstract
The antitumor activity of several 13-alkyl-berberrubine and newly synthesized ester derivatives was tested using experimental tumors (S-180, NF sarcoma, Ehrlich carcinoma and L-1210) in mice. For chemotherapeutic evaluation, the therapeutic indices and ratios were determined. In berberrubine derivatives, the 9-demethyl structure was essential for the manifestation of antitumor activity; ester derivatives also exhibited a remarkable antitumor activity, and the 13-methyl derivatives of both berberrubine and palmatrubine alkaloids showed high antitumor activity.

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