Convection-enhanced delivery of immunotoxins and radioisotopes for treatment of malignant gliomas
- 1 April 2006
- journal article
- review article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Neurosurgical Focus
- Vol. 20 (4) , E13
- https://doi.org/10.3171/foc.2006.20.4.8
Abstract
✓ The treatment of malignant gliomas has advanced significantly in the past 15 years. The simultaneous development of new targeting agents and techniques to deliver these high-molecular-weight compounds has led to improved efficacy and promising results in Phase III trials. Convection-enhanced delivery (CED) of macromolecules has emerged as the leading delivery technique for the treatment of malignant gliomas. A summary of the basic principles of CED and a review of the current human trials of protein targeting agents are provided.Keywords
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