Faculty Opinions recommendation of Leptin regulates bone formation via the sympathetic nervous system.

8 June 2020

dataset
Published by H1 Connect

https://doi.org/10.3410/f.718689309.793575334

Abstract

Bone remodelling allows vertebrates to regulate bone mass, and osteoblasts can control osteoclast differentiation. This paper investigates the role of leptin in this mechanism, where the authors demonstrate that it inhibits bone formation and is mediated by sympathetic signalling via β₂-adrenergic receptors (β₂-ADR) on osteoblasts. This Recommendation is of an article referenced in a Faculty Review also written by Claire Fielding and Simón Méndez-Ferrer.

Keywords

NEUROBIOLOGY OF DISEASE & REGENERATION
NEURONAL & GLIAL CELL BIOLOGY
INTEGRATIVE PHYSIOLOGY
NEURAL HOMEOSTASIS
HEMATOPOIESIS
STEM CELLS & REGENERATION
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