Exploiting the Cold-Urticaria Model

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Abstract
Although cold urticaria is sometimes scarcely more than a minor annoyance, there is substantial disability in more severe cases, and occasionally it may result in death from swimming in cold water. In addition to the clinical importance of cold urticaria, however, there is the possibility that progress in understanding this intriguing problem may provide insights into the broader and common problem of chronic idiopathic urticaria, which is frustrating to patients and physicians alike. Cold urticaria is one of the "physical allergies" that can sometimes be passively transferred by serum to normal skin by the Prausnitz–Kustner technique, with the sensitized sites . . .

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