INDUCTION OF ABORTION WITH SULPROSTONE, A UTEROSELECTIVE PROSTAGLANDIN-E2 DERIVATIVE - INTRAMUSCULAR ROUTE OF APPLICATION

  • 1 January 1981
    • journal article
    • research article
    • Vol. 26  (2) , 86-93
Abstract
Sulprostone, a new prostaglandin E2 derivative with high selectivity for the uterine muscle, was tested in 180 women (62 primigravida) for induction of abortion in the 1st trimester, or pregnancy by i.m. administration. Total dosages from 500-1500 .mu.g in single injections of 500 .mu.g were tested. The injections were given at intervals of 4-8 h. Adequate cervical dilatation was achieved in nearly 94% of the patients, with complete abortion in more than 50%. No sulprostone-related complications, such as shock or cramps, were registered. Side effects were at a tolerable level with concomitant medication being necessary for about one third of the patients. Optimal effectiveness and acceptability were recorded at an injection interval of 6-8 h and a total dose of 1000 .mu.g sulprostone. The application of sulprostone as abortifacient in the 1st trimester pregnancy is discussed.