Age and beta adrenoceptor–mediated function

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Abstract
.beta.-Adrenoceptor-mediated responsiveness to isoproterenol was compared in young and old [human] subjects using the production of cyclic AMP by lymphocytes as an index. The mean log dose-response curve for the elderly group was displaced to the right and the mean maximum response was less than that for the young subjects. The results corroborate evidence of a decreased response to isoproterenol-induced increases in heart rate in the elderly and raise the possibility of a generalized decrease in .beta.-adrenoceptor-mediated functions in old age.