Lipid composition and de novo lipid biosynthesis of human palmar fat in Dupuytren's disease

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Abstract
Seventy-two surgically obtained Dupuytren's disease palmar-fat (DDPF) specimens and 18 location-matched speciments from patients not suffering from this disease (controls) were studied for their total lipid composition and de novo lipogenic activity. Incubation of “DDPF” with 1-[14C]acetate in oxygen produced [14C]palmitate and [14C]stearate in approximately equal yields as those obtained from “controls”. No [14C]octanate was formed in any of the palmar-fat preparations. The lipids and fatty acid analysis revealed differences; (a) DDPF specimens were richer in free fatty acids, methyl esters of fatty acids and freecholesterol than specimens of controls (b) DDPF specimens contained less phospholipids. (c) DDPF specimens showed a significantly higher content of octanoate and other short-chain fatty acids than specimens of controls. The above findings are not incompatible with the results expected if some mild hypoxia occurred in DDPF; this has been suggested in the statistical correlations observed for this disease and alcoholism with liver involvement.