CHEMOTHERAPEUTIC ACTIVITY OF X-5079C IN SYSTEMIC MYCOSES OF MAN

Publisher Website
Google Scholar
Abstract
Twenty-eight systemic mycotic infections in 27 patients have been treated with X-5079C, a polypeptide antibiotic. The diseases treated include histoplasmosis (8 cases), blastomycosis (6 cases), coccidiodomycosis (6 cases), aspergillosis (2 cases), sporotrichosis (3 cases), Candida endocarditis (2 cases), and maduromycosis ( one case). The drug was administered subcutaneously every 6 hours, and the maximal daily dosage was ususally 4 mg/kg (range 3 to 17 mg/kg). The duration of therapy was ususally 4 weeks (range 1 to 10 weeks). X-5079C appears to be an active agent in histoplasmosis, blastomycosis, aspergillosis, sprortrichosis, and maduromycosis. No benefit was observed in cases of coccidioidomycosis or Candida endocarditis.