EFFECTS OF DIURETICS ON THE VASOCONSTRICTOR RESPONSES TO NOREPINEPHRINE AND POTASSIUM-IONS IN THE RAT MESENTERIC-ARTERY

  • 1 January 1983
    • journal article
    • research article
    • Vol. 262  (1) , 124-131
Abstract
The effects of 4 different diuretics, hydroflumethiazide, furosemide, piretanide and potassium canrenoate on the vascular responses to norepinephrine and KCl in the perfused rat mesenteric vascular bed were studied. Furosemide or piretanide in the perfusate inhibited the vascular response to norepinephrine in a dose-related manner, while the vascular contraction induced by KCl was not affected by these substances. In contrast to furosemide and piretanide, potassium canrenoate inhibited vascular responses to both norepinephrine and K+. Hydroflumethiazide did not induce any change in the vascular response to norepinephrine or to KCl. Furosemide, piretanide and potassium canrenoate, but not hydroflumethiazide have direct vascular actions independent from their renal actions which may contribute to their antihypertensive effects.