Morphologic and Hemodynamic Changes in the Smaller Blood Vessels in Diabetes Mellitus

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Abstract
SINCE the most serious problem in diabetes mellitus today is the associated vascular degeneration, a proper understanding of the pathology and pathogenesis of these changes is essential. This is particularly true in the light of the recent report that the retinal changes in diabetes may be reversible,1 giving hope that a rational therapy may be found if causative factors are known. There is rapidly accumulating evidence that the lesions in the smaller blood vessels are most characteristic of the generalized abnormality of the vessel walls. The structural integrity of the walls of the larger vessels is dependent on the function . . .