Studies in Hypersensitiveness

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Abstract
Summary: Neither the localization of the clinical manifestations of atopic hypersensitiveness nor their severity is dependent upon the degree of sensitiveness as determined by any method of clinical testing. Individuals sensitive to pollen (early and late hay fever) can be classified by the intradermal method into A, B and C groups, depending upon the degree of skin sensitivity. This classification serves as a guide in the treatment of cases (R. A. Cooke). Hay fever patients can also be classified, with the scratch method, into groups corresponding to the A, B and C classes of the intradermal method, but solutions 500, 100 and 30 times as strong must be employed in the respective groups. The eye (conjunctival) test is less sensitive than the intradermal, and more sensitive than the scratch method, but cannot be used with any degree of accuracy to classify pollen cases into A, B and C groups. It is an excellent test to determine the presence, but not the degree, of pollen sensitivity.

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