Clinical Diagnosis in Patients with Smooth Muscle Antibodies

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Abstract
Out of 17109 sera tested for autoantibodies by indirect immunofluorescence, 236 contained smooth muscle antibodies (SMA) with a titre of ≥1/25. The majority of these sera, from 190 patients, reacted both with smooth muscle and renal glomerull and the specificity of these SMA is against actin. 91% of high-titred sera (≥1/100) with IgG antibodies giving this staining pattern were derived from patients with chronic inflammatory liver disease, mainly chronic active hepatitis. In the group with a titre of 1/25, non-liver diseases such as joint diseases were more common and liver conditions occurred only in 55%. Sera with SMA of IgM class were mostly derived from patients with acute viral hepatitis.