Persistent Effects of Prenatally Administered Scopolamine

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Abstract
Acute effects of anticholinergic drugs on behavior are well documented (Warburton, 1975); however, evidence of chronic effects of these drugs administered prenatally is practically nonexistent. Three groups of pregnant rats were given daily injections of 2.4 mg/kg scopolamine, 1.2 mg/kg scopolamine, or 1.0 or .5 cc saline. A fourth group served as a no-injection control. Treatment was continued throughout pregnancy and 17 offspring were subsequently tested in a shock-drinking conflict situation. Offspring of the low-dose scopolamine group tolerated significantly more shock than other groups.