EFFECT OF PANCURONIUM AND GALLAMINE ON MUSCARINIC TRANSMISSION IN SUPERIOR CERVICAL GANGLION

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 204  (1) , 46-53
Abstract
Pancuronium enhanced contraction of the nictitating membrane elicited via ganglionic muscarinic pathways in the superior cervical ganglion of the cat. Recordings of the superior cervical ganglion surface potential were made which demonstrated that pancuronium and gallamine reduced and haloperidol enhanced ganglionic hyperpolarization without significantly altering the ganglionic slow depolarization. Pancuronium reversed the effects produced by haloperidol, whereas the latter drug was unable to antagonize those induced by pancuronium. These results allowed the speculation that pharmacologically distinct muscarinic receptors resided in sympathetic ganglia, 1 of which was susceptible to blockade by pancuronium or gallamine.