Appraisal of Certain Factors Influencing Compensatory Renal Hypertrophy

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Abstract
Marked reduction in blood flow to the kidney frequently resulted in decrease in size of the kidney and minimized or prevented compensatory renal hypertrophy. Degenerative changes often occurred in the kidneys of which the blood flow was restricted. Restriction of intake of water could prevent compensatory renal hypertrophy over a short period, but the animals during that period stopped eating and lost considerable weight. Restriction of intake of inorganic salts did not prevent the occurrence of the expected degree of compensatory renal hypertrophy. If after unilateral uretero-duodenostomy, the corresponding kidney was not damaged as a result of ureteral obstruction, the contralateral kidney did not significantly increase in size during a period of 3 weeks. This suggests that excretory work is not the only factor of importance in compensatory renal hypertrophy and that the presence of renal tissue, even though it is not accomplishing excretory function for the body influences compensatory renal hypertrophy.