Survival of in situ carcinoma of cervix uteri: A 50‐year follow‐up in Finland

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Abstract
Preinvasive lesions of cervix uteri are regarded a curable disease despite some progression to invasive cancer. The ultimate outcome is not known. We estimated the 45‐year survival of 12,655 patients with carcinoma in situ lesions diagnosed in 1953–2000 and reported to the Finnish Cancer Registry. Up to 30 years of follow‐up there was about 1% decrease in cumulative relative survival per 5 years of follow‐up. After that the excess mortality increased and the survival at 45 years was 84%. The 15‐year survival was 100% in the patients under 30 at diagnosis and became the poorer the older the patient. Survival was 89% in the patients 60–74 at diagnosis. Women with carcinoma in situ are at substantial increased risk of death (>10%) only at high ages and independent of age at diagnosis.