Lithium therapy and thyroid function: a long-term study
- 1 February 1981
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 11 (1) , 85-92
- https://doi.org/10.1017/s0033291700053307
Abstract
SYNOPSIS Seventy-three patients who had been continuously receiving lithium carbonate for 6 months or more had their thyroid function evaluated clinically and biochemically. Goitre was found in 37 %, exophthalmos in 23 %, positive thyroid auto-antibodies in 24 % and abnormal TRH tests in 49 %. It would appear that thyroid failure due to lithium is usually dependent on antibody mediated damage. It is unlikely that lithium has a direct effect on the hypothalamic–pituitary axis.Keywords
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