Dopamin-Rezeptor-Blockade, ein möglicher Wirkungsmechanismus antipsychotisch wirksamer Pharmaka

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Abstract
Antipsychotic drugs of various types inhibit dopamine-sensitive adenylate cyclase (EC 4.6.1.1) while structurally related drugs that were not clinically effective as antipsychotic drugs were almost inactive. These results are discussed in relation to the suggestion that antipsychotic activity may be related to the blockade of dopamine receptors in the brain.