Strain differences in the facilitative effects of 5-7-diphenyl-1-3-diazadamantan-6-01 (1757 I.S.) on maze learning.

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Abstract
Rats were injected either with the strychnine-like drug 1757 I.S. or a citric acid control solution 10 min. before being run in a Lashley III alley maze. From 2 to 5 massed trials were given on each of 4 days. Injections did not affect differentially the performance of descendants of the Tryon "maze-bright" (S-sub(1)) strain, but in descendants of the "maze-dull" (S-sub(3)) strain and in 1st-generation cross-bred Ss, the 1757 I.S. Ss made significantly fewer errors. It is suggested that S-sub(3) Ss normally have slower rates of intertrial neural reverberation than S-sub(1) Ss, and that the slow rate of reverberation and consolidation of S-sub(3) Ss was increased by 1757 I.S. From Psyc Abstracts 36:05:5DP02M. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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