On the Specificity of Human Anti‐H Antibodies
- 1 May 1986
- journal article
- research article
- Published by Wiley in Vox Sanguinis
- Vol. 50 (4) , 223-226
- https://doi.org/10.1111/j.1423-0410.1986.tb04886.x
Abstract
Anti-H antibodies from 2 homogeneous subgroups of H-deficient individuals (Bombay and Réunion phenotypes) were studied for their specificity with regard to synthetic H oligosaccharides. It appears that Bombay individuals synthesize large amounts of both anti-H type 2 and anti-H type 1 antibodies, whereas Réunion individuals may possess strong anti-H type 1 antibodies, but have only weak anti-H type 2 antibodies in their serum. This can be explained by the presence of small amounts of H-type 2 determinants on the erythrocytes of Réunion individuals contrasting with the complete lack of H determinants on the red cells of Bombay individuals.Keywords
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