Reduction of methionine sulfoxide to methionine by Escherichia coli

Abstract
L-Methionine-dl-sulfoxide can support the growth of an E. coli methionine auxotroph, suggesting the presence of an enzyme(s) capable of reducing the sulfoxide to methionine. This was verified by showing that a cell-free extract of E. coli catalyzes the conversion of methionine sulfoxide to methionine. This reaction required NADPH and a generating system for this compound. The specific activity of the enzyme increased during logarithmic growth and was maximal when the culture attained a density of about 109 cells/ml.

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