CARDIOVASCULAR EFFECTS OF ALCURONIUM IN MAN
Open Access
- 1 July 1970
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 42 (7) , 625-630
- https://doi.org/10.1093/bja/42.7.625
Abstract
We have investigated the effects of alcuronium (0.15 mg/kg body weight) on heart rate, stroke volume, cardiac output, mean arterial blood pressure and total peripheral resistance in 22 artificially ventilated patients anaesthetized with 60 per cent nitrous oxide in oxygen, plus either tubocurarine (25–35 mg, according to body weight) and 0.2 per cent methoxyflurane—series I—or phenoperidine (1 mg/15 kg body weight)—series II. End-tidal Pco2 was maintained constant. The most striking effect was a significant increase of heart rate in the series II patients, accompanied by a significant fall of cardiac output and of stroke volume. There was no significant change of mean arterial pressure in either series of patients; therefore the fall of cardiac output was accompanied by a compensatory increase of total peripheral resistance.Keywords
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