Comparative Natriuretic and Diuretic Efficacy of Theophylline Ethylenediamine and of Bendroflumethiazide during Long‐Term Treatment with the Potent Diuretic Bumetanide

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Abstract
The additive natriuretic and diuretic effects of theophylline ethylenediamine and of bendroflumethiazide have been compared in permutation trial tests in patients with advanced congestive heart failure receiving long‐term treatment with the highly potent diuretic, bumetanide. Statistical analysis of renal water and electrolyte excretion revealed that theophylline ethylenediamine, 400 mg orally, and bendroflumethiazide, 5 mg orally, had very similar effects, both quantitatively and qualitatively. The mechanism of action of the supplementary diuretics is discussed. It is concluded that theophylline ethylenediamine represents a useful alternative to thiazide diuretics when supplementary natriuretic treatment is considered in patients with congestive heart failure during long‐term treatment with potent diuretics. The significance of maintaining the potassium balance during such a combined regimen is stressed.