Plaque Inhibition Test for Detection of Specific Inhibitors of DNA Containing Viruses

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Abstract
5-Iodo-and 5-bromo-2[image]-depxyuridine, when tested in the agar-diffusion plaque-inhibition test, were found to inhibit plaque formation of DNA containing vaccinia and herpes simplex viruses but not RNA containing West Nile and Newcastle disease viruses. A number of other compounds that might be candidates for the disruption of normal nucleic acid biosynthesis, including aminopterin and 5-fluoro-2[image]-deoxyuridine, also were tested and found inactive in this test system. Thymidine readily reversed plaque inhibition by both 5-iodo-and 5-bromo-2[image]-deoxyuridine.

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