A Possible Mechanism of Action of Quinidine

Publisher Website
Google Scholar
Abstract
Quinidine increases the refractory period and depresses both the rate and amplitude of beat of isolated rabbit atria. These effects can be enhanced by elevating the K content of the medium twofold and completely blocked by lowering the K to one-sixteenth the normal amount. Small amounts of acetylcholine act in a manner similar to low K. These observations suggest that quinidine produces its effects by depressing outward flux of K ions. Ion transport studies revealed this to be the case. The hypotheses that quinidine in final analysis acts by blocking the intracellularly released acetylcholine is presented and discussed.

This publication has 0 references indexed in Scilit: