Coding and Noncoding Genomic Regions of Entamoeba histolytica Have Significantly Different Rates of Sequence Polymorphisms: Implications for Epidemiological Studies
- 1 September 2005
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 43 (9) , 4815-9
- https://doi.org/10.1128/jcm.43.9.4815-4819.2005
Abstract
To evaluate genetic variability among Entamoeba histolytica strains, we sequenced 9,077 bp from each of 14 isolates. The polymorphism rates from coding and noncoding regions were significantly different (0.07% and 0.37%, respectively), indicating that these regions are subject to different selection pressures. Additionally, single nucleotide polymorphisms (SNPs) potentially associated with specific clinical outcomes were identified.Keywords
This publication has 23 references indexed in Scilit:
- Comparative Genomic Hybridizations ofEntamoebaStrains Reveal Unique Genetic Fingerprints That Correlate with VirulenceEukaryotic Cell, 2005
- The genome of the protist parasite Entamoeba histolyticaNature, 2005
- Stable SNPs in Malaria Antigen Genes in Isolated PopulationsScience, 2004
- Geographic Diversity among Genotypes of Entamoeba histolytica Field IsolatesJournal of Clinical Microbiology, 2003
- Genotyping ofEntamoebaSpecies in South Africa: Diversity, Stability, and Transmission Patterns within FamiliesThe Journal of Infectious Diseases, 2003
- Remarkable Genetic Polymorphism among Entamoeba histolytica Isolates from a Limited Geographic AreaJournal of Clinical Microbiology, 2002
- Introns of Entamoeba histolytica and Entamoeba disparProtist, 2001
- Recent Origin of Plasmodium falciparum from a Single ProgenitorScience, 2001
- Isolation and Characterization of Polymorphic DNA from Entamoeba histolyticaJournal of Clinical Microbiology, 2001
- FREQUENCY DISTRIBUTION OF ENTAMOEBA HISTOLYTICA ZYMODEMES IN A RURAL SOUTH AFRICAN POPULATIONThe Lancet, 1985