Effects of Superoxide Dismutase and Catalase on Endotoxin Shock in Rats

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Abstract
The effects of superoxide dismutase (SOD) and catalase on endotoxin-induced experimental shock were studied in rats. Experimental shock was induced by a single intravenous injection of endotoxin at a dose of 100mg/kg. After the injection, systolic blood pressure was reduced and heart rate was increased. Activities of serum lysosomal enzymes, such as acid phosphatase, β-glucuronidase, and cathepsin B, were increased. Serum thiobarbituric acid-reactive substances, which are important and damaging products of free radical lipid peroxidation, were significantly increased. These changes were most remarkable at 45min after the injection of endotoxin. By the subcutaneous injection of SOD (50mg/kg) 12 and 1h before the administration of endotoxin (100mg/kg), the reduction of systolic blood pressure and the increase in serum acid phosphatase, β-glucuronidase, and cathepsin B activities were significantly inhibited. By the subcutaneous injection of catalase (1.0mg/kg) 12 and 1h before the treatment with endotoxin, the decrease in systolic blood pressure and the increase in acid phosphatase and cathepsin B activities were significantly inhibited. These results indicate that oxygen-derived free radicals, such as superoxide and hydrogen peroxide, can affect the experimental shock states.

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