Human Growth Hormone Secretion after Exercise and Oral Glucose Administration in Patients with Short Stature

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Abstract
Human growth hormone (hGH) response to severe exercise and glucose administration was compared with that during insulininduced hypoglycemia on 16 normal subjects aged 9 to 16, 22 patients with prepubertal short stature and delayed adolescence, 4 patients with pubertal short stature and 9 patients with pituitary dwarfism. Nine out of 13 patients with prepubertal short stature and delayed adolescence showed no or blunted response to exercise despite of demonstrating normal response to hypoglycemia. Eight out of 15 patients with the same disease showed no or subnormal response of hGH rebound after glucose administration, although they had a normal response to hypoglycemia. All normal subjects and patients with pubertal short stature showed no such dissociation in hGH secretion, while patients with pituitary dwarfism showed no response to this stimulation. These data suggest that there is a physiological disturbance in hGH secretion in patients with constitutional short stature even if hGH secretion is confirmed to be normal in unphysiological hypoglycemia.

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