Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing
- 1 September 1981
- journal article
- review article
- Published by Springer Nature in Human Genetics
- Vol. 58 (3) , 235-254
- https://doi.org/10.1007/bf00294917
Abstract
Data from previous studies published on the induction by mutagens of sister chromatid exchanges (SCEs) and structural chromosome damage were compared qualitatively and quantitatively. Although a good correlation between the incidence of both cytogenetic phenomena has been pointed out in many previous publications, about 30% of the agents for which comparable data were available yielded non-corresponding qualitative results concerning both indicator effects. However, even in the group with good qualitative agreement distinct quantitative differences indicated different molecular mechanisms of the formation of SCEs and breaks. Additional information supporting the importance of these differences for the validity of both indicator systems has been derived from the results obtained using strong clastogens exhibiting a low or no SCE-inducing activity and vice versa, from special observations on chromosomal breakage syndromes, and from studies on the action of known co- and anti-clastogens on SCE-induction by chemical mutagens. As a result, it has been suggested that the SCE-technique should be considered as a valuable additional method for cytogenetic mutagenicity testing, which, however, is not adequate to replace the classical methods of analysis of structural chromosome damage.Keywords
This publication has 254 references indexed in Scilit:
- Studies on the ultraviolet light sensitivity of Bloom's syndrome fibroblastsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
- The use of harlequin staining to measure delay in the human lymphocyte cell cycle induced by in vitro X-irradiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
- Increased sensitivity of cell strains from Cockayne's syndrome to sister-chromatid-exchange induction and cell killing by UV lightMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
- The effect of washing lymphocytes after in vivo treatment with streptonigrin on the yield of chromosome and chromatid aberrations in blood culturesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
- Anthramycin-induced sister-chromatid exchange and caffeine potentiation in the chromosomes of Indian muntjacMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1979
- Greater Promotion in Sister Chromatid Exchanges by Trimethylpsoralen than by 8-Methoxypsoralen in the Presence of UV-LightJournal of Investigative Dermatology, 1978
- Aging and sister chromatid exchangeExperimental Cell Research, 1978
- Effect of cocultivation on sister chromatid exchange frequencies in Bloom's syndrome and normal fibroblast cellsNature, 1978
- Sister chromatid exchanges induced in chinese hamster cells by UV irradiation of different stages of the cell cycle: The necessity for cells to pass through SMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
- Chromosomenaberrationen bei Busulfan-Behandlung*Deutsche Medizinische Wochenschrift (1946), 1974