Pantothenic Acid Deficiency in Cholesterol-fed Hamsters

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Abstract
A 5-week study of hamsters fed a pantothenic acid-deficient diet, with and without cholesterol, is reported. The adverse effect of pantothenate deficiency on growth was greater in the cholesterol-fed female hamster than in the male. Pantothenic acid deficiency did not prevent the accumulation of lipid in the liver of the hamster as it did in the rat. However, cholesterol feeding resulted in even greater increases in liver and plasma cholesterol of the hamster than those of the rat. The lack of cholesterol in the hamster adrenal points to an unusual path of steroid metabolism, which needs further study.