The Related Genes Encoding Growth Hormone and Prolactin Have Been Dispersed to Chromosomes 10 and 17 in the Rat*
- 1 December 1986
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 119 (6) , 2451-2454
- https://doi.org/10.1210/endo-119-6-2451
Abstract
We have assigned the rat GH gene to chromosome 10 and the rat PRL gene to chromosome 17. DNA from a series of mouse BWTG3 .times. rat hepatocyte somatic cell hybrids, each of which has retained a unique complement of rat chromosomes, was analyzed for the presence of rat GH and PRL genomic fragments by Southern blotting. Radiolabeled complementary DNAs (cDNAs) encoding rat GH and rat PRL were used as molecular probes. Based upon these assignments, we conclude that the evolutionarily revealed GH and PRL genes have been dispersed to different chromosomes in rat as in man.This publication has 3 references indexed in Scilit:
- The Prolactin Gene Is Located on Chromosome 6 iIn HumansScience, 1981
- Control of serum protein production in hepatocyte hybridomas: immortalization and expression of normal hepatocyte genes.Proceedings of the National Academy of Sciences, 1980
- Structure of cloned DNA complementary to rat prolactin messenger RNA.Journal of Biological Chemistry, 1980