The metabolism of sulphapyridine containing radioactive sulphur in the rabbit
- 1 March 1950
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 46 (3) , 267-271
- https://doi.org/10.1042/bj0460267
Abstract
Sulfapyridine containing S35 was synthesized. Metabolic expts. with this compound in the rabbit showed that there is no complete catabolism to inorganic sulfate and no significant retention of the drug in the tissues after 3 days. Differences between the values obtained by assays of S35 and diazotizable material suggested the formation of a metabolite which does not diazotize or couple normally, but this has not yet been isolated.This publication has 5 references indexed in Scilit:
- The fate of certain organic acids and amides in the rabbit: 2. p-Hydroxybenzoic acid and its amide.1947
- The fate of certain organic acids and amides in the rabbitBiochemical Journal, 1947
- Studies on mustard gas (betabeta'-dichlorodiethyl sulphide) and some related compounds: 3. The preparation and use of mustard gas containing (a) radioactive sulphur and (b) deuterium.1946
- The metabolism of sulphapyridine in the rabbitBiochemical Journal, 1946
- Studies in the sulphur metabolism of the dogBiochemical Journal, 1932