Antibiotic Concentrations in Septic Joint Effusions

Publisher Website
Google Scholar
Abstract
Fifty specimens from 27 infants and children with septic joint disease were assayed for ampicillin (18 specimens), methicillin (14 specimens), penicillin (14 specimens) or cephalothin (four specimens). The ranges of observed values varied depending upon the dose and the interval after administration. The joint-fluid level was the same as or higher than the serum level in eight of nine paired specimens tested for ampicillin and in seven of 11 paired specimens assayed for methicillin. Comparable serum and joint-fluid levels of penicillin were found in 11 of 12 paired specimens.

This publication has 11 references indexed in Scilit: