GROWTH INHIBITORY EFFECT OF LH-RH ANALOGS ON HUMAN-BREAST CANCER-CELLS
- 1 January 1988
- journal article
- research article
- Vol. 8 (1) , 187-190
Abstract
The antiproliferative effect of two LH-RH agonists (Pro-9-LH-RH ethylamide and D Ser(t BU)6 Aza Gly 10-LH-RH, ICI 118630) on the human breast cancer cell line CG5 is reported. Although ineffective when used alone, both analogs inhibited in a dose-dependent fashion the growth stimulatory effect of estradiol. LH-RH analogs did not influence the growth inhibitory effect of tamoxifen and medroxyprogesterone acetate. Likewise, these compounds neither modified basal estrogen and progesterone receptor levels nor prevented estrogen-induced increase of progesterone receptor. A marked antiproliferative effect of the analogs was also seen in cells stimulated with other mitogens, such as insulin and epidermal growth factor.This publication has 7 references indexed in Scilit:
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