Altered Erythrocyte Membrane Protein Phosphorylation in an Unusual Case of Hereditary Spherocytosis
- 1 September 1979
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 23 (3) , 251-255
- https://doi.org/10.1111/j.1600-0609.1979.tb02700.x
Abstract
Membrane protein phosphorylation was examined in several members from a family with an unusual form of hereditary spherocytosis. After incubation of membrane ghosts with (.gamma.-32P) ATP, the phosphorylation of spectrin component II was diminished in the absence and presence of c[cyclic]AMP. In the presence of this nucleotide, the phosphorylation of components IV5 and IV8 was also decreased. Along with a previously reported alteration of a membrane neutral phosphatase in this family, these abnormalities remove the present condition from the usual form of hereditary spherocytosis.Keywords
This publication has 16 references indexed in Scilit:
- Properties of a non-specific nucleotidase in the membrane of rabbit red cellsBiochimica et Biophysica Acta (BBA) - Enzymology, 1977
- Isoelectric focusing of spectrin components in hereditary spherocytosisClinica Chimica Acta; International Journal of Clinical Chemistry, 1976
- Studies on protein kinase activity and the binding of adenosine 3′5-monophosphate by membranes of hereditary spherocytosis erythrocytesBiochemical and Biophysical Research Communications, 1975
- Defective protein phosphorylation in membranes of hereditary spherocytosis erythrocytesFEBS Letters, 1974
- Erythrocyte Protein PhosphorylationJournal of Biological Chemistry, 1973
- The role of cyclic AMP in the phosphorylation of proteins in human erythrocyte membranesBiochemical and Biophysical Research Communications, 1973
- Phosphorylation of an Endogenous Membrane Protein by an Endogenous, Membrane-associated Cyclic Adenosine 3′,5′-Monophosphate-dependent Protein Kinase in Human Erythrocyte GhostsJournal of Biological Chemistry, 1972
- Cyclic Adenosine 3′,5′-Monophosphate-dependent Protein Kinase of Human Erythrocyte MembranesJournal of Biological Chemistry, 1972
- Electrophoretic analysis of the major polypeptides of the human erythrocyte membraneBiochemistry, 1971
- The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytesArchives of Biochemistry and Biophysics, 1963