Phosphofructokinase activity in fibroblasts from patients with Alzheimer's disease and age- and sex-matched controls
- 1 March 1986
- journal article
- conference paper
- Published by Springer Nature in Metabolic Brain Disease
- Vol. 1 (1) , 83-90
- https://doi.org/10.1007/bf00998479
Abstract
The activity of the enzyme phosphofructokinase (PFK) was comparable in cultured skin fibroblasts from eight patients with Alzheimer's disease and eight age- and sex-matched controls. Mean activities were similar in the two groups whether measured under nonallosteric conditions at pH 8.0 or under allosteric conditions at pH 7.0, in the presence of 0.1 or 1 mM ATP. Activities of PFK in Alzheimer's disease and control cells also showed a similar temperature dependence and similar isozyme patterns on column chromatography. These results argue against the existence of significant structural variations of PFK in Alzheimer's disease.Keywords
This publication has 27 references indexed in Scilit:
- Quantitating the OccultNew England Journal of Medicine, 1985
- Altered Calcium Uptake in Cultured Skin Fibroblasts from Patients with Alzheimer's DiseaseNew England Journal of Medicine, 1985
- Alzheimer’s diseaseNeurochemical Pathology, 1984
- Regional cortical dysfunction in Alzheimer's disease as determined by positron emission tomographyAnnals of Neurology, 1984
- Computed Tomography and Positron Emission Transaxial Tomography Evaluations of Normal Aging and Alzheimer's DiseaseJournal of Cerebral Blood Flow & Metabolism, 1983
- Muscle phosphofructokinase deficiency. Biochemical and immunological studies of phosphofructokinase isozymes in muscle culture.Journal of Clinical Investigation, 1983
- Metabolic Processes in Alzheimer's Disease: Adenine Nucleotide Content and Production of 14CO2 from [U‐14C]Glucose In Vitro in Human NeocortexJournal of Neurochemistry, 1983
- Phosphofructokinase (PFK) isozymes in manHuman Genetics, 1979
- ACCELERATED AGEING OR SELECTIVE NEURONAL LOSS AS AN IMPORTANT CAUSE OF DEMENTIA?The Lancet, 1979
- HUNTINGTON'S CHOREA: POST MORTEM ACTIVITY OF ENZYMES INVOLVED IN CEREBRAL GLUCOSE METABOLISMJournal of Neurochemistry, 1977