Translating cell biology in vitro to immunity in vivo
- 8 July 2004
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 430 (6996) , 264-271
- https://doi.org/10.1038/nature02762
Abstract
The elimination of pathogens and pathogen-infected cells initially rests on the rapid deployment of innate immune defences. Should these defences fail, it is the lymphocytes — T cells and B cells — with their antigen-specific receptors that must rise to the task of providing adaptive immunity. Technological advances are now allowing immunologists to correlate data obtained in vitro with in vivo functions. A better understanding of T-cell activation in vivo could lead to more effective strategies for the treatment and prevention of infectious and autoimmmune diseases.Keywords
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