Highly Enantioselective Catalytic Phenylation of Ketones with a Constrained Geometry Titanium Catalyst
- 6 September 2003
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (20) , 3641-3644
- https://doi.org/10.1021/ol0352963
Abstract
[reaction: see text] The catalytic asymmetric addition of phenyl groups from diphenylzinc to ketones is reported. The catalyst, generated from a dihydroxy bis(sulfonamide) ligand and titanium tetraisopropoxide, gives good to excellent enantioselectivities with a range of substrates.Keywords
This publication has 8 references indexed in Scilit:
- Highly enantioselective arylation of ketonesTetrahedron: Asymmetry, 2003
- Phenyl versus Ethyl Transfer in the Addition of Organozinc Reagents to Aldehydes: A Theoretical StudyAngewandte Chemie International Edition in English, 2003
- Highly enantioselective addition of dialkylzinc reagents to ketones promoted by titanium tetraisopropoxideTetrahedron: Asymmetry, 2002
- Enantioselective additions of diphenylzinc to aldehydes using chiral pyrrolidinylmethanol derivatives as catalystsTetrahedron: Asymmetry, 2001
- A Synthetic Azinomycin Analogue with Demonstrated DNA Cross-Linking Activity: Insights into the Mechanism of Action of this Class of Antitumor AgentPublished by Wiley ,2000
- First enantioselective addition of dialkylzinc to ketones promoted by titanium(IV) derivativesTetrahedron Letters, 1998
- Enantioselective addition of organozinc reagents to aldehydesChemical Reviews, 1992
- Two-dimensional chemical exchange NMR in the solid: proton dynamics in phthalocyanineJournal of the American Chemical Society, 1986