Radioprotecting action of chemical compounds on γ-irradiated yeast cells of various genotypes

1 September 1981

journal article
Published by Springer Nature in Molecular Genetics and Genomics

Vol. 183 (1) , 152-157
https://doi.org/10.1007/bf00270154

Abstract

The radioprotective efficiency of cysteamine and cysteine has been studied on haploid and diploid, Saccharomyces cerevisiae, wild-type and various X-ray repair deficient rad mutants. The correlation between the radioprotecting action of cysteamine and cell repair capacity was demonstrated for diploid yeasts; such a correlation was not expressed for wild-type and rad mutant haploid yeast cells. It was concluded that the radioprotective action may involve cellular recovery processes, which may be mediated by a recombination-like mechanism, for which the diploid state is required. Liquid holding recovery was shown not to participate in radioprotection, judged by the absence of the influence of cysteine on the delay of the first postradiation budding as well as by the additive action of cysteine and liquid holding recovery.

Keywords

WILD TYPE

This publication has 12 references indexed in Scilit:

RBE of densely ionizing radiation for wild-type and radiosensitive mutants of yeast
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1981
Genetic analysis of γ-mutagenesis in yeast III. Double-mutant strains
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
Effect of elevated temperatures on the radiation sensitivity of yeast cells of different species
Radiation and Environmental Biophysics, 1979
Mechanism of the radioprotecting action of chemical compounds on Escherichia coli cells
Molecular Genetics and Genomics, 1978
DNA Repair and the Genetic Control of Radiosensitivity in Yeast
Basic life sciences, 1975
Chemical Protection of Bacteria and Cultured Mammalian Cells by Sulfur-Containing Compounds
Journal of Radiation Research, 1975
A genetic study of X-ray sensitive mutants in yeast
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
Interactions among genes controlling sensitivity to radiation and alkylation in yeast
Molecular Genetics and Genomics, 1973
Cellular Repair Processes: Survival of Irradiated Yeast, Bacteria, and Phages Under Different Postradiation Conditions
Published by Elsevier ,1968
Two types of radiation-sensitive mutant in yeast
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1967