Adjuvant Activity of a Nontoxic Mutant ofEscherichia coliHeat-Labile Enterotoxin on Systemic and Mucosal Immune Responses Elicited against a Heterologous Antigen Carried by a LiveSalmonella entericaSerovar Typhimurium Vaccine Strain
Open Access
- 1 July 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (7) , 6382-6390
- https://doi.org/10.1128/iai.68.7.4349-4353.2000
Abstract
Systemic and mucosal antibody responses against both the major subunit of colonization factor antigen I (CFA/I) of enterotoxigenicEscherichia coli(ETEC) and the somatic lipopolysaccharide expressed by recombinant bivalentSalmonellavaccine strains were significantly enhanced by coadministration of a detoxified derivative with preserved adjuvant effects of the ETEC heat-labile toxin, LT(R192G). The results further support the adjuvant effects of LT(R192G)and represent a simple alternative to improve responses against passenger antigens expressed by orally deliveredSalmonellavaccine strains.Keywords
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