Zur Darstellung von O-Acyl-Derivaten des Carnitins

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Abstract
O-acyl derivatives of the optical isomers of carnitine were prepared from the carnitine betaines with the acid chloride alone or with the addition of the corresponding carboxylic acid. There were hardly any by-products. The chlorides of the acyl derivatives of optically active carnitine were obtained in practically theoretical yield. The racemic form of carnitine, reacted with n- or iso-buty-ryl chloride and with caproyl-chloride to give lower yields; DL-carni-tine chloride was isolated from the raction mixture. The chlorides, perchlorates and tetrachloroaurates of the prepared acyl-carnitines are described. In addition, the reineckates, hexachloroplatinates, mercury double salts and picrates were prepared. The free betaines are easily prepared from the chlorides and perchlorates. Some questions of nomenclature of carnitine are briefly discussed.